Cool mod idea! I recommend moving landfill earlier in the tech tree or making it so the landfill tech and it's prerequisites are not affected by the science cost multiplier. For example If you have a 100x multiplier, to unlock the landfill tech alone it is 5k red/green science and this is not really doable on just the small amount of landfill you begin with. Similarly with the agricultural tower.

Interesting, I've never played around with the science cost multiplier so I didn't really consider it here. I don't really like the idea of moving landfill in the tech tree - one of my design goals was to avoid touching existing parts of the game as much as possible (outside of things that HAD to change like foundation). That's why the sediment to stone recipe is very generous rather than making landfill cheaper, for example. I also like the bit of early-game challenge that comes from limited space until you research landfill, when you're playing with default settings.

Given this is an issue specifically with science multiplier, I'd be open to opting a few techs out of the multiplier like you suggest. I guess that would be:

• Logistic Science Pack
• Steel Processing
• Landfill
• Agriculture